Cohorts and biobanks
The research conducted by the SIRIC teams within each of the integrated research programs relies on clinico-biological cohorts and on databases related to imaging, epidemiology, public health, and quality of life.
NEO EPICURE : In Silico Prediction of Pathological Response in a Prospective Cohort Study of Early-Stage Breast Cancer Patients
Coordinator : Jean-Sébastien Frenel, ICO.
Clinical Research Protocol: Interventional research involving human subjects, NCT05981326
NEOEPICURE is a cohort study including 100 new cases of HER2+ breast cancer and 100 patients with early-stage triple-negative breast cancer, treated with neoadjuvant chemotherapy with or without immunotherapy. This cohort will compile digitized pathological data, imaging data, and genomic, transcriptomic, and proteomic data. Analyses are conducted on tumor samples before treatment and on resistant tumors for patients who do not achieve a complete pathological response. These various analyses aim to test new drugs in vitro or to better understand resistance in the context of innovative molecules.
MYRACLE : Study of clonal evolution mechanisms and treatment resistance in multiple myeloma.
Coordinator : Cyrille Touzeau, CHU de Nantes
Clinical Research Protocol: Non-interventional research involving human subjects, NCT03807128
MYRACLE is a prospective cohort of patients with multiple myeloma, supported by a biobank dedicated to identifying mechanisms of resistance to various treatments. The data collected in the MYRACLE study include socio-demographic, clinical, biological, imaging, treatment, and quality of life data, gathered at different stages of patient management (diagnosis, relapse/progression, follow-up). This integrative cohort of 600 patients will ultimately allow for the determination, through bioinformatics treatments, of biomarkers that influence treatment response, and the assessment of the impact of each treatment on clonal evolution and key resistance factors such as apoptosis and the P53 network.
Public health databases
CONSTANCES Cohort: Study of Professional and Social Determinants of Health
Launched in 2009, the CONSTANCES cohort is the largest epidemiological and public health survey in France, conducted by Inserm and the health insurance funds (Cnam and CPAM). This epidemiological cohort aims to follow 200,000 volunteer adults aged 19 to 69 years, focusing on four main themes: occupational risks, aging, social health inequalities, and specific women’s health issues. This national database is open to the research community and is utilized for public health projects, research, and epidemiological monitoring.
Within the SICAJOB program, co-directed by Yves Roquelaure, epidemiological data from CONSTANCES are used to better understand the dynamics of returning to work and maintaining sustainable employment after breast cancer. The Ester team collaborates with INSERM UMS 11 (M. Zins, M. Goldberg) for coding the socio-professional trajectories of the cohort.
Loire-Atlantique Vendée Cancer Registry: A comprehensive and ongoing registry of cancers diagnosed in residents of Loire-Atlantique or Vendée since 1998, serving public health surveillance and research missions.
Director : Florence Molinié.
The primary objective of the registry is to contribute to public health monitoring and planning by regularly producing local indicators. The data from the registry are used for national, regional, and departmental incidence estimates, as well as for estimating cancer patient survival in France.
The registry’s research focus is on evaluating diagnostic/screening practices and general population management without selection bias. The registry particularly develops such studies on breast cancer, with routine data collection including more numerous and precise items compared to other cancers. Studying geographic and social disparities is another key research area. Registry data are also used for studies initiated by other local or national organizations.