DYRK1A, related kinases & human disease conference | Saint-Malo, France | October 19-23, 2021
After the successful first edition of the « DYRK1A, related kinases & human disease » conference in March 2017, the second edition is scheduled from 19 to 23 October 2021 in Saint-Malo.
DYRKs (‘dual specificity, tyrosine phosphorylation regulated kinase 1’) (DYRK1A, 1B, 2, 3, 4) play key roles in mRNA splicing, chromatin transcription, DNA damage repair, cell survival, cell cycle, differentiation, endocytosis, neuronal development and functions, synaptic plasticity, folate and methionine metabolism. Inhibition of DYRKs may find applications in Down syndrome, Alzheimer’s disease and tauopathies, Parkinson’s disease, CDKL5 Deficiency Disorder diabetes, osteoarthritis, viral infections and various cancers. The closely related CLKs (‘cdc2-like kinases) (CLK1, 2, 3, 4) also play essential functions in Alzheimer’s disease and tauopathies, alternative splicing, various viral infections, cancers, body temperature sensing.
The conference will focus on DYRK1A and related kinases, including structural, regulatory and functional aspects, substrates and interactors, functions at cell and organism levels as well as development and potential therapeutic use of selective pharmacological inhibitors.
Important dates :
- Very early bird registration deadline : June 30, 2021
- Early bird registration deadline : August 6, 2021
- Late registration : August 6, 2021 up to September 15, 2021
- Start of the conference : October 19, 2021 at 17:00
- End of the conference : October 23, 2021 at 12:00