Welcome to Jane Jardine, post-doctoral student in cellular and molecular biology at SIRIC ILIAD!
After a Master’s degree in BioSciences at the Ecole Normale Supérieure (ENS) in Lyon and a PhD in Cellular and Molecular Biology at the University of Liverpool, Jane Jardine joined the programme 2 of SIRIC ILIAD in January 2021.
Her work within the CRCINA team 15 is focused on the new Research on Extracellular Vesicles (REVs) operating desk.
The study of extracellular vesicles (EVs) is a rapidly growing field in clinical, translational and fundamental research. EVs represent a privileged mode of communication between tumour cells and their microenvironment. They are a source and a resource of information on tumour progression, response to treatment and dissemination.
Angers and Nantes represent two nationally recognised centres of excellence in the study of nanoparticles. In this context, CRCINA team 15 is frequently called upon to analyse extracellular vesicles. The team has thus set up an operational Research on Extracellular Vesicles (REVs) desk. It is dedicated to the discovery of presumed circulating biomarkers linked to tumour progression and is open to researchers and clinicians specialising in cancer.
Subject / Missions:
Jane Jardine will participate in the operation of the REV desk by providing guidance, assistance and/or ready-to-use data, from isolation to the characterisation of extracellular vesicles from liquid biopsies, using standardised and validated procedures (EV-track.org). She will also be involved in the implementation of advanced methodologies and technologies for the automated isolation and characterisation of biological nanomaterials.
EVs and cancer:
- Ghoroghi S, Mary B, Larnicol A, Asokan N, Klein A, Osmani N, Busnelli I, Delalande F, Paul N, Halary S, Gros F, Fouillen L, Haeberle AM, Royer C, Spiegelhalter C, André-Grégoire G, Mittelheisser V, Detappe A, Murphy K, Timpson P, Carapito R, Blot-Chabaud M, Gavard J, Carapito C, Vitale N, Lefebvre O, Goetz JG, Hyenne V. Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes. eLife 2021; 10: e61539.
- Sabbagh Q, Andre-Gregoire G, Guevel L, Gavard J. Vesiclemia: Counting on Extracellular Vesicles for Glioblastoma Patients. Oncogene 2020; 39(38): 6043-52.
- Treps L, Perret R, Edmond S, Ricard D, Gavard J. Glioblastoma stem-like cells secrete the pro-angiogenic VEGF-A factor in extracellular vesicles. J Extracell Ves. 2017; 1(6).