The laboratories and teams of the SIRIC ILIAD
The SIRIC ILIAD is based upon multidisciplinary laboratories and teams that allow them to aim for excellence in integrated translational research in the fight against cancer.
Fundamental and translational research
The Nantes – Angers Cancer and Immunology Research Center (CRCI²NA, INSERM U 1307 – CNRS UMR 6075), was created in January 2022 by INSERM, CNRS, Nantes University and the University of Angers. Formerly the CRCINA (Centre de Recherche en Cancérologie et Immunologie, UMR1232) from 2017 to 2021, the project of the CRCI²NA is to explore the interactions and dynamic changes of tumour ecosystems during tumour progression, as well as the mechanisms of dissemination in response to treatments. The CRCI²NA teams have multidisciplinary expertise in oncology, from basic research to translational research, thanks to the involvement of clinicians. Bringing together 12 teams from both Nantes and Angers and counting more than 300 collaborators, the CRCI²NA is the largest research centre dedicated to cancer in the Grand Ouest.
The Arronax GIP has the job of accompanying research development into nuclear medicine and its related fields (physics, chemistry and radiobiology), industrial production and training. All the operations are ensured by highly qualified personnel who intervene on the accelerator (Groupe GAMO), concerning aspects of radioprotection (SPR), administrative aspects (SGE) and for Research and Development (R&D).
The R&D group brings together physicists, chemists and radiopharmacists dedicated to developing the production of non-conventional radionuclides for research and also for the pharmaceutical industry (raw material for pharmaceutical use), as well as radiodrugs (called radiopharmaceuticals) for clinical trials. The activities are managed according to the good practices in fabrication directives (BPF) and are certified ISO-9001.
Bioinformatics, mathematics and statistics
The LAREMA (The Mathematical Research Laboratory of Angers) is a laboratory for pure and applied mathematics (CNRS UMR 6093) currently made up of about fifty members divided into two teams: « Algebra and Geometry » and « Analysis, Probabilities and Statistics ». The latter has directed a large part of its research towards applications in life sciences over the last few years. Today, this direction is characterised by their collaboration with regional research clusters in the fields of plants or health , in particular concerning the problems of modelling or data analysis.
The LS2N- SIMS, COMBI and MeForBio teams
- The Nantes Laboratory of Digital Sciences (LS2N) is a research unit attached to the CNRS (UMR 6004), the Ecole Centrale of Nantes, the University of Nantes, the Atlantic Mines Telecom Institute and INRIA. The LS2N brings together Nantes’ skills in the subject of research into informatics and cybernetics so as to develop digital sciences, by integrating other disciplines and societal challenges.
The Signals, Images and Sounds (SIMS) team : statistical processing of signals and images in order to design new tools for extracting pertinent information from sounds or images and to provide solutions in diverse areas of activity. The strong points of the SIMS team in the SIRIC ILIAD are their expertise in the resolution of inverse problems, applied to imaging data in nuclear medicine and their skills in designing modern automatic learning methods for the analysis of medical images.
The Jean Leray Mathematics Laboratory
The Jean Leray Mathematics Laboratory (LMJL, UMR CNRS 6629) is made up of five teams from Nantes dedicated to i) the analysis of partial differential equations, ii) the mathematics of randomness iii) geometry and global analysis, iv) modelling, digital analysis and scientific calculation and v) topology, geometry and algebra.
HSS, epidemiology, public health
The IRSET – Ester Team
The Institute of Research into Health, Environment and Work (IRSET, UMR Inserm 1085) is a research centre dedicated to studying the biological processes and environmental determinants (chemical, biological, physical, sociocultural, occupational, geographical and economic) that influence human health. The « Occupational health epidemiology and ergonomics » team (ESTER) directed by Yves Roquelaure specialises in the study of these determinants and in the prevention of health problems such as occupational cancers, psychosocial factors at work and musculoskeletal disorders, in the following axes: i) etiological research into occupational determinants, specifically in the organisation of work, psychosocial factors and managerial practice, ii) the contribution of social inequality and health, iii) evaluating occupational exposure, and iv) integrated prevention that encourages a return to work and the retention of a job in the long-term. The transdisciplinary and interdisciplinary research programme combines methods in epidemiology, ergonomics, public health, and clinical research.
The SPHERE Laboratory
The SPHERE unit (Results Methodology focusing on the patient & HEalth ResEarch) is a mixed research unit (UMR Inserm 1246) that aims to promote methodological research which focuses on the patient and reinforces the contribution of data reported by the patients (quality of life, tiredness, well-being …) in the decision-making process and care assessment. Three interdependent research axes have been developed with an interdisciplinary perspective: i) measurement and interpretation of how the patients perceive and experience things, ii) true assessment of the patient’s environment, and iii) stratified medicine centred around the patient. The objectives are, therefore, to offer methods better adapted to evaluating and understanding how patients adjust to their illness and to better interpret the results provided by the patients, taking into account the patient’s environment in the pragmatic evaluation of their care and prognosis, in order to integrate the patients’ perspectives and preferences into medical decision-making and prognostic assessment.
The LEMNA team (Nantes Atlantique Economics and Management Laboratory) brings together researchers in management and economics from the University of Nantes, the Atlantic Mines Telecom Institute (IMT Atlantique) and Oniris (Veterinary and Food Engineering). The research topics of the laboratory are divided into four axes: i) transformation at work, ii) environmental, marine and energy challenges, iii) digital and organisational transformations, iv) evolution of companies and financial markets.
The Cancer Registry of the Loire Atlantique and Vendee
Since 1998 the cancer registry of the Loire Atlantique and Vendee has made a census of all the new cases of cancer that concern people residing in the Loire Atlantique or Vendee and has published several epidemiological indicators (incidence, survival) by locality, sex, age and year of diagnosis. With a population of 2 million inhabitants, the Loire-Atlantique Vendee Registry is the largest registry in France and one of the 2 registries that collect detailed data on the characteristics of breast cancer; in this capacity they coordinate several national and international projects (incidence, care, evaluation of the efficiency of screening programmes…) and are a member of the European Cancer Network (European Network of Cancer Registries, ENCR).